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What is methadone hydrochloride and how does it work?
Methadone is used to treat opioids (such as heroin) as part of an approved treatment program. Methadone belongs to a class of medicines called opioid analgesics. It helps to prevent withdrawal symptoms caused by discontinuation of other opioids.

Methadone can also be used to treat severe pain. Do not use methadone to relieve pain that is mild or it will disappear within a few days. Methadone is not for temporary use ("as needed").

Methadone is available under the following different brands and names: Metados and Dolofine. dosages
of methadone hydrochloride dosage forms and strengths for

Injectable solution: Scheme II
10 mg / ml

Tablet: Skema II

5 mg
10 mg
40 mg (barn)

Dispersing tablets: Skema II

40 mg

Oral solution: Schedule II

5 mg / 5 ml
10 mg / 5 ml

Oral concentrate solution: Scheme II

10 mg / ml

Dosage - should be administered as follows:
For adults with chronic severe pain
To treat pain that is high enough to require a 24-hour daily long-term opioid treatment and for which alternative treatment options are not sufficient

Opioid naive patients: 2.5 mg orally every 8-12 hours; Do not vibrate slowly with the dose any more often than every 3 days

Opioid-tolerant patient

Stop all other opioids around the clock
Significant interpatient variations, see prescribed instructions

Opioid-tolerant definition

Using the higher starting dose of non-opioid patients can fatally cause respiratory depression
Patients who are opioid-tolerant are those who receive oral morphine at least 60 mg per day for 1 week or longer, 25 micrograms per hour transdermal fentanyl is 30 mg per day oral oxycodone, 8 mg per day oral hydromorphone, 25 mg per day oral oxymorphone or a balance dose of another opioid

Restrictions on use Applying the risk of addiction and dependence of opioids and even recommended doses, and due to the increased risk of overdose and death associated with prolonged opioid release, patients may retain alternative treatment (eg, non-opioid analgesics or immediate release opioids)) ineffective, not tolerated, or otherwise inadequate to allow adequate pain management
Not indicated for acute pain or as a painkiller

20-30 mg taken orally once daily or minimally suppressive pressures can be divided into 40 mg / day in divided doses and continue for 2-3 days, then 20%
Daily dose tolerated dose reductions are titrated

Renal insufficiency (CrCl less than 10 ml / min): 50-75% of the normal dose

Hepatic impairment: Not recommended for severe liver disease

Dosage treatment
Change from oral to parenteral: Parenteral to oral ratio, 1: 2 (5 mg parenteral = 10 mg taken orally)

To switch from another opioid to methadone, use available conversion factors to reach the estimated dose.
Does not stop methadone suddenly in a physically dependent patient.

Pain (off-label)
0.7 mg / kg / day Oral / Sc / Intravenous (IV) / Intramuscular (IM) divided as needed every 6 hours Do not exceed 10 mg / dose
Opiate day

Newborn: 0.05-0.2 mg / kg is taken orally once every 12-24 hours; reduce the dose by 10-20% per week for 4-6 weeks; Adjust drop signs and symptoms of withdrawal from

2.5 mg oral or intramuscular (IM) once every 8-12 hours. Slowly, the dose rises more often than every third day.

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20-30 mg are taken orally once a day, or the minimum dose necessary to suppress withdrawal.

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Methadone is a long-term opioid drug used to treat pain and addiction. Formulations The 5 mg and 10 mg indicated for the treatment of pain continue to be available to all authorized registrants, including pharmacies.

DEA and the pharmaceutical industry agree that the reported increase in methadone-related adverse events that give rise to the action, and also in line with extensive efforts to ensure this, will be properly distributed in accordance with its authorized uses. The industry and the federal agencies concerned are committed to monitoring the progress of this initiative.

This drug is a narcotic analgesic.

The regulation
Secretion of growth hormone (GH) from the pituitary gland is regulated by the hypothalamic neurosecretion nuclei. These cells release hormone-containing hormone (GHRH or somatocrinin) peptides and growth hormone-inhibiting hormone (somatostatin or GHIH) in the portal pituitary

Category: Pain Meditations